Intersect a list of bigWig files with a GRanges object and aggregate by name

Usage

.multi_bw_ranges_aggregated(
  bwfiles,
  labels,
  granges,
  per_locus_stat,
  aggregate_by,
  remove_top,
  default_na = NA_real_,
  scaling = "none"
)

Arguments

bwfiles: Path or array of paths to the bigWig files to be summarized.
labels: List of names to give to the mcols of the returned GRanges object. If NULL, file names are used.
granges: GRanges object to summarize. Should have a valid name field.
per_locus_stat: Aggregating function (per locus). Mean by default. Choices: min, max, sd, mean.
aggregate_by: Statistic to aggregate per group. If NULL, values are not aggregated. This is the behavior by default.
remove_top: Return range 0-(1-remove_top). By default returns the whole distribution (remove_top == 0).
default_na: Default value for missing values
scaling: If none, no operation is performed (default). If relative, values are divided by global mean (1x genome coverage).

Value

An aggregated dataframe