Calculate heatmap matrix of a bigWig file over a GRanges or BED file
Source:R/bwtools.R
bw_heatmap.RdCalculates a matrix of values that corresponds to the usual heatmaps where each row is a locus and columns are data points taken each bin_size base pairs.
Usage
bw_heatmap(
bwfiles,
bg_bwfiles = NULL,
loci = NULL,
labels = NULL,
mode = "stretch",
bin_size = 100,
upstream = 2500,
downstream = 2500,
middle = NULL,
ignore_strand = FALSE,
norm_mode = "fc",
default_na = NA_real_,
scaling = "none"
)Arguments
- bwfiles
Path or array of paths to the bigWig files to be summarized.
- bg_bwfiles
Path or array of paths to the bigWig files to be used as background.
- loci
BED file or GRanges to summarize
- labels
List of names to give to the mcols of the returned GRanges object. If NULL, file names are used.
- mode
How to handle differences in lengths across loci:
stretch: Anchor each locus on both sides.
start: Anchor all loci on start.
end: Anchor all loci on end.
center: Center all loci.
- bin_size
Bin size. Length of bin in base pairs. The lower, the higher the resolution.
- upstream
Number of base pairs to include upstream of loci.
- downstream
Number of base pairs to include downstream of loci.
- middle
Number of base pairs that the middle section has (in stretch mode). If not provided, median length of all loci is used.
- ignore_strand
Whether to use strand information in BED file.
- norm_mode
Function to apply to normalize bin values. Default fc: divides bw / bg. Alternative: log2fc: returns log2(bw/bg).
- default_na
Default value for missing values
- scaling
Whether to use the bigWig values as they are (none - default) or calculate relative enrichment (relative) by dividing values by global average.
Details
Loci are aligned depending on mode parameter:
stretch. Aligns all starts and all ends, sort of stretching the loci. The median of these lenghts is taken as the pseudo-length in order to show a realistic plot when displayed.
start. All loci are aligned by start.
end. All loci are aligned by end.
center. All loci are aligned by center.
Examples
# Get the raw files
bed <- system.file("extdata", "sample_genes_mm9.bed", package="wigglescout")
bw <- system.file("extdata", "sample_H33_ChIP.bw", package="wigglescout")
bw2 <- system.file("extdata",
"sample_H3K9me3_ChIP.bw", package="wigglescout")
# Heatmaps with a single bigWig
h <- bw_heatmap(bw, loci = bed, mode = "stretch")
# h is a list
h[[1]]
#> [,1] [,2] [,3] [,4] [,5] [,6] [,7]
#> [1,] 1.5571400 1.8089556 1.7986790 1.0123983 1.8192324 1.1357364 1.1717091
#> [2,] 8.3767061 6.5471879 6.7065003 5.5604854 6.2748153 6.7630298 7.4156929
#> [3,] 2.1224406 0.8582262 1.5211672 1.7061734 2.3691158 1.9477097 0.8530865
#> [4,] 1.6136704 1.7370100 2.5644019 2.1686913 1.3413000 1.8295119 2.5027331
#> [5,] 1.3772726 1.7524260 2.5232881 2.2200822 1.8552061 1.2436579 0.7400293
#> [6,] 0.7194702 0.6166896 0.7451677 0.9507299 0.2312586 1.1049009 0.4625176
#> [7,] 0.5550224 0.2312586 0.1901460 1.0226773 1.4286646 1.5211664 1.3156047
#> [8,] 0.8376697 0.7451665 1.4492204 1.3567189 1.4543599 0.8119761 1.4235240
#> [9,] 2.2509161 1.8706254 2.1173007 1.8397888 1.5468623 1.8500670 1.0946228
#> [10,] 2.7648248 2.6312092 1.9991032 1.3669958 3.7463895 3.1040046 2.5489831
#> [11,] 3.2633155 3.8800045 2.5695400 1.5417250 2.5181490 2.5695400 2.5952355
#> [12,] 0.4625172 1.1562923 0.7451690 0.8736465 2.0299362 2.7494072 3.8029186
#> [13,] 1.5468614 1.1049029 1.3361603 2.2252218 1.3464388 2.7545476 1.4029700
#> [14,] 4.0084826 2.6980170 1.6445045 2.3125854 2.7494074 2.0813273 1.7986769
#> [15,] 3.0269174 3.6538856 5.0722715 3.5202708 3.4637402 5.5707629 4.3116878
#> [16,] 3.3147070 2.5387044 1.8346502 1.7421482 2.3331434 3.0988650 2.7339900
#> [17,] 3.0269174 3.6538856 5.0722715 3.5202708 3.4637402 5.5707629 4.3116878
#> [18,] 1.0329562 0.8582266 0.5087704 2.8676081 1.1460154 1.4338043 1.3053268
#> [19,] 1.0329562 0.8582266 0.5087704 2.8676081 1.1460154 1.4338043 1.3053268
#> [20,] 1.0329562 0.8582266 0.5087704 2.8676081 1.1460154 1.4338043 1.3053268
#> [21,] 1.3104660 0.4265438 1.2590766 2.6466276 1.3567169 0.8273938 1.4029689
#> [22,] 1.2899089 0.4316835 1.7061761 2.0299376 1.5365852 0.7914203 1.3618561
#> [23,] 2.3742551 1.5622796 1.0380940 2.0556300 1.3567154 1.6753383 1.5314454
#> [24,] 2.4050894 1.6188098 0.8685047 2.0402127 1.4286625 1.6033912 1.4338025
#> [25,] 5.8071602 6.7065044 6.4135713 5.5502069 3.7720845 3.2376210 3.5922169
#> [26,] 7.3797190 8.6799109 9.0653429 5.3446431 6.9120665 6.0384193 6.5523267
#> [27,] 8.2482264 4.2654370 3.2890120 5.2932531 2.8007985 1.6188089 0.7708634
#> [28,] 1.5108897 2.1532759 1.3618573 1.9631267 1.5006102 1.8449291 2.1275793
#> [,8] [,9] [,10] [,11] [,12] [,13] [,14]
#> [1,] 2.4718974 1.886041 3.8029185 3.30443017 3.2633155 3.5151315 4.0495953
#> [2,] 5.7506317 7.246103 5.4165912 1.61880851 4.0495958 4.2757146 4.9026832
#> [3,] 1.2282414 1.654783 1.0021208 0.06166896 0.4625165 3.0320570 2.7288519
#> [4,] 2.1789709 1.063791 0.6423854 1.52116740 0.6423840 1.6804772 2.1635521
#> [5,] 1.1871268 2.410229 1.1717110 2.41022947 1.3772729 2.1429965 3.0988658
#> [6,] 0.7451678 0.719472 0.4882134 0.92503332 0.1798678 2.1841107 1.2847709
#> [7,] 1.8809029 1.526307 1.1100404 0.53446581 0.7605854 1.6496429 1.4594992
#> [8,] 2.2766123 1.870625 1.5365838 1.22310071 0.5447431 0.6886385 0.5704381
#> [9,] 1.0483733 1.798676 2.5592620 1.73187072 1.3772733 3.0115019 1.0997642
#> [10,] 2.6569032 4.265435 3.2838719 3.88000451 2.5592618 1.5314468 2.5387054
#> [11,] 2.3382795 1.978547 1.7729819 1.46463631 1.0278170 0.3854312 0.3854324
#> [12,] 2.6466270 2.338281 1.8757630 1.10490192 1.5417233 1.0021202 2.9806655
#> [13,] 2.8110752 2.276612 4.6097546 4.77934450 5.4422854 4.3939129 6.2593989
#> [14,] 2.4410625 1.438942 1.5674200 2.10702150 2.2098035 1.5417243 1.3104648
#> [15,] 5.7454922 5.252140 7.4722233 6.27481609 7.6675083 5.9613325 8.5925497
#> [16,] 3.7618057 2.399951 2.2663331 1.68561822 2.3125850 1.4440806 2.2920289
#> [17,] 5.7454922 5.252140 7.4722233 6.27481609 7.6675083 5.9613325 8.5925497
#> [18,] 1.3978298 2.805938 2.8470506 2.72885144 4.2191858 2.6774611 3.1502566
#> [19,] 1.3978298 2.805938 2.8470506 2.72885144 4.2191858 2.6774611 3.1502566
#> [20,] 1.3978298 2.805938 2.8470506 2.72885144 4.2191858 2.6774611 3.1502566
#> [21,] 1.9991020 3.150257 2.4153670 3.74125064 3.3249859 2.8984422 3.2941503
#> [22,] 2.4256453 3.114283 2.5078708 4.05473445 3.1142841 2.9858056 2.9858056
#> [23,] 2.0916042 2.076186 3.0526139 3.90569898 3.0731688 2.4410625 3.6384693
#> [24,] 2.1892471 1.922013 3.1502568 3.80805639 3.0988640 2.4564798 3.5254099
#> [25,] 2.9498333 3.258176 1.4286642 1.88090251 2.5644005 1.5108890 0.7760024
#> [26,] 3.3558198 3.854310 3.6076347 3.06803122 3.5202700 1.8346523 1.9477097
#> [27,] 0.9250330 1.695896 2.2868890 1.95285002 2.7751010 2.5438450 1.7729826
#> [28,] 1.4594997 1.901461 1.3978290 1.01753752 2.2200836 0.9969813 1.3412999
#> [,15] [,16] [,17] [,18] [,19] [,20]
#> [1,] 3.8543096 3.4431831 7.0148478 5.7352126 5.3806166 2.980667
#> [2,] 6.8658127 4.3990529 4.9900464 3.9468132 3.9159785 4.244879
#> [3,] 3.4431837 2.3382810 1.8500681 1.9631295 3.0783086 3.551105
#> [4,] 1.9631261 3.3712352 1.6907579 2.8419109 2.1275796 1.058652
#> [5,] 3.0731712 4.0650116 3.9416739 4.1009857 4.5223906 3.026918
#> [6,] 1.4903330 2.1584127 1.4646387 1.8243715 2.8778855 1.824374
#> [7,] 1.8089569 1.1049026 0.5139094 1.1922679 1.5314480 3.504853
#> [8,] 1.8860416 1.0329548 0.9661472 1.0997629 1.3156038 1.377274
#> [9,] 1.2487959 1.2385183 1.4594972 0.6372459 0.6834970 1.238520
#> [10,] 2.5592618 2.6055137 2.2971669 2.0402156 1.7832601 1.444080
#> [11,] 0.4368224 1.3104667 2.3125860 2.7237130 4.9849075 4.393913
#> [12,] 1.8500665 2.7751020 1.4903322 0.5909960 0.0770862 1.336160
#> [13,] 7.2872197 5.6786829 6.5626043 4.2037675 2.7339902 4.686841
#> [14,] 1.5160293 1.0278175 0.8736464 1.6958950 1.8500680 2.595235
#> [15,] 8.4537940 11.0284778 13.5877240 16.6711912 12.8785339 12.986463
#> [16,] 2.8367727 2.7494085 2.0093816 2.3896720 1.9528515 1.146014
#> [17,] 8.4537940 11.0284778 13.5877240 16.6711912 12.8785339 12.986463
#> [18,] 2.5078702 0.8736454 2.2355009 2.2509171 3.0320585 3.098865
#> [19,] 2.5078702 0.8736454 2.2355009 2.2509171 3.0320585 3.098865
#> [20,] 2.5078702 0.8736454 2.2355009 2.2509171 3.0320585 3.098865
#> [21,] 1.4389419 1.2590765 2.0761889 2.9858061 3.1142830 2.847051
#> [22,] 1.1408762 1.7986798 1.7832602 3.2067874 3.2787334 2.389671
#> [23,] 2.9498324 3.2530374 4.5378096 5.3806170 4.9797683 7.276939
#> [24,] 3.0371963 3.2633155 4.2140473 5.6067371 4.7073969 6.994288
#> [25,] 1.7986750 1.8500670 1.3361597 1.5006103 2.1224393 1.978544
#> [26,] 1.6753401 2.1018835 1.2796306 1.4594980 2.0042390 1.295047
#> [27,] 2.7494070 3.2633155 2.5438445 2.8007995 2.9035794 2.929273
#> [28,] 2.6363483 4.0238993 3.7258330 3.6024951 4.2757137 4.239741
#> [,21] [,22] [,23] [,24] [,25] [,26] [,27]
#> [1,] 2.3125865 0.9455904 0.3545975 1.1151793 1.1511538 3.131816 3.5793247
#> [2,] 2.4975926 3.4534612 1.9734059 2.1892479 1.8038153 2.819550 2.1250773
#> [3,] 3.6949984 5.0208791 4.7279523 5.2007475 4.5943371 5.877454 4.7566360
#> [4,] 1.5879739 1.1357367 1.7472870 1.2231009 1.9271545 2.408943 2.3018800
#> [5,] 2.9035801 1.3515768 1.1357373 0.8530886 1.0278152 3.542782 4.3659452
#> [6,] 2.1841095 2.5438445 1.6445055 1.9271542 1.9271550 3.597360 3.5973599
#> [7,] 2.5746783 3.3969336 3.7720862 4.6765627 4.4144700 5.276956 5.0082669
#> [8,] 1.0021232 0.9815655 1.3104651 0.8171161 1.6239481 2.350189 2.4333229
#> [9,] 2.1841075 3.0012220 1.0535132 1.6239501 1.9836864 3.002834 4.2100918
#> [10,] 1.0380950 0.3854312 0.4059888 0.4162660 1.2590759 2.224681 2.6709696
#> [11,] 3.8800055 2.4667580 2.4667580 2.2354985 3.1348395 2.569540 2.5695400
#> [12,] 2.5695400 2.2868895 2.7494075 2.7237130 3.4431835 2.807460 1.7659731
#> [13,] 4.1832111 3.6949974 3.2067869 4.8564301 4.2448811 5.637415 4.4360868
#> [14,] 0.9764246 1.3361603 0.8479508 0.3597364 0.7451678 1.852834 0.9861477
#> [15,] 11.6965614 14.2095499 10.0212073 8.3201806 4.0187605 4.808784 5.2771038
#> [16,] 1.6033941 2.2354990 3.2427601 1.6804792 3.0474740 2.652123 1.3345590
#> [17,] 11.6965614 14.2095499 10.0212073 8.3201806 4.0187605 4.808784 5.2771038
#> [18,] 1.8397913 2.8984414 2.5900959 1.8140954 1.1974054 1.445049 2.4728644
#> [19,] 1.8397913 2.8984414 2.5900959 1.8140954 1.1974054 1.445049 2.4728644
#> [20,] 1.8397913 2.8984414 2.5900959 1.8140954 1.1974054 1.853740 2.2648667
#> [21,] 1.5263062 3.3712376 2.1943862 1.3824136 1.0226762 2.262314 2.3516874
#> [22,] 1.8809041 3.2787338 2.0556305 1.2590752 0.7554451 2.785382 2.4513412
#> [23,] 8.4794869 8.3047554 6.7219167 7.4979197 8.1094697 7.181365 5.8865805
#> [24,] 8.5154612 8.7210217 6.2285645 7.6418139 8.0529397 7.398959 6.3070508
#> [25,] 2.9909447 3.4329039 2.9549695 3.0577524 3.0115021 3.143320 3.4210143
#> [26,] 1.7370068 1.8346523 1.7832582 2.5900954 3.0680300 3.214259 3.3684336
#> [27,] 3.4174871 4.9592120 5.0106020 7.6572305 9.0447869 6.993620 6.4988642
#> [28,] 3.3558179 5.3189485 5.5399267 5.3600609 5.1956091 4.813077 7.0446346
#> [,28] [,29] [,30] [,31] [,32] [,33] [,34]
#> [1,] 2.587572 2.4342999 3.5187573 3.0533953 2.5635285 2.662705 2.617907
#> [2,] 1.666726 1.1944887 2.3195297 5.4029803 3.2640089 2.472314 4.055708
#> [3,] 7.218614 5.0681971 4.9777366 3.3404014 6.8402956 5.545426 6.752513
#> [4,] 1.667578 2.3125850 2.6980164 2.0346551 2.9870919 2.997798 3.408576
#> [5,] 2.907638 3.5200423 3.8838709 2.6912543 3.6701215 2.587572 1.964675
#> [6,] 3.597360 2.0556300 2.0556300 2.0556300 2.0556300 2.055630 1.541720
#> [7,] 4.562879 3.7352341 3.8465245 3.4104800 1.6507332 3.669429 3.285895
#> [8,] 1.667066 0.9968587 1.3474412 1.9379879 0.9349422 1.641999 2.346641
#> [9,] 2.821457 3.6566539 3.4965892 4.2199756 4.2926424 1.640552 2.184108
#> [10,] 2.907638 5.6529877 3.9286903 5.4568927 2.2382033 2.569540 2.366681
#> [11,] 2.312585 2.0556300 2.0556300 1.5417200 1.5417200 1.541720 1.541720
#> [12,] 1.817711 3.0647609 0.1868756 1.3704180 1.7846606 2.284034 4.157983
#> [13,] 1.890839 3.5361297 1.8844361 0.9672048 1.6821215 2.058141 1.742106
#> [14,] 1.780158 1.2130095 0.7268799 1.6551550 0.7245644 1.252363 1.152821
#> [15,] 4.282781 3.4159065 3.2476543 2.3799739 3.4881618 4.502116 6.091990
#> [16,] 1.713493 3.4916309 3.3921841 2.3064598 1.5155824 1.680988 2.476497
#> [17,] 4.282781 3.4159065 3.2476543 2.3799739 3.4881618 4.502116 6.091990
#> [18,] 2.126170 2.8086862 2.6854212 2.1166901 1.6374506 2.315129 1.738218
#> [19,] 2.126170 2.8086862 2.6854212 2.1166901 1.6374506 2.315129 1.738218
#> [20,] 2.455747 2.4630877 1.8867757 2.4300502 1.6591876 2.444734 3.270657
#> [21,] 2.016532 2.8789912 2.5862974 2.0053584 2.1164159 1.994185 2.385203
#> [22,] 2.040216 2.4462016 2.6106532 2.3948105 1.6599223 2.410228 1.495472
#> [23,] 3.937738 2.6896739 4.2313987 4.1112627 5.1657770 4.551757 4.157982
#> [24,] 3.870997 2.6563031 4.3352753 4.0244993 5.1457543 4.538409 4.210091
#> [25,] 3.718277 5.7336019 4.6705165 6.7157298 8.4845258 8.791861 6.176972
#> [26,] 2.705025 3.1348385 3.4936307 3.9103746 5.6296292 4.970892 7.727312
#> [27,] 6.497724 3.8718661 3.2909270 3.3179190 2.0364801 1.830797 2.062016
#> [28,] 6.017479 4.1271821 1.6141691 1.1756208 2.1348679 2.608196 2.614817
#> [,35] [,36] [,37] [,38] [,39] [,40] [,41]
#> [1,] 3.0173305 3.7626488 2.8069577 1.7079871 1.9654732 1.4305280 1.7941691
#> [2,] 3.7084705 1.9861827 4.2362665 3.3195687 2.5973189 4.9585194 4.4029401
#> [3,] 7.5255045 6.6150709 5.0076158 3.7804732 2.1333147 2.0795339 3.7863804
#> [4,] 3.7579529 2.8264952 1.6885531 2.5267142 2.0556300 1.7724563 0.8565150
#> [5,] 1.6918039 1.5327070 1.6417766 1.7736660 0.9106096 1.2779475 0.5815287
#> [6,] 1.5417200 1.5417200 1.5417200 1.5417200 1.5417200 1.5417200 1.5417200
#> [7,] 3.4385117 2.4449566 2.2530475 2.0930059 2.0805482 1.1119101 0.4794393
#> [8,] 1.2722369 1.5293381 0.9463410 1.2073741 2.0432472 2.0368301 3.2815816
#> [9,] 2.1664749 1.9568012 2.1160900 1.5417219 1.1285828 1.9469186 1.3200382
#> [10,] 2.2111554 2.7250654 3.0766860 1.1630540 2.2179186 1.9812502 2.4613497
#> [11,] 1.5417200 2.0556300 2.0556300 2.0556300 2.0556300 2.0556300 1.5417200
#> [12,] 3.1488551 1.9509472 2.8031364 2.5695400 3.5402562 3.6907944 0.7518300
#> [13,] 0.8796986 0.8732961 0.8185522 0.7779026 0.4724952 0.9587544 0.9802315
#> [14,] 1.9726691 0.8171609 1.6945068 1.9167377 1.1620802 1.6898774 0.8333641
#> [15,] 4.0329238 3.6529432 3.6776221 3.0133667 3.8305974 2.7167086 2.9761729
#> [16,] 3.2249184 2.7372937 2.4221974 2.2872963 3.9625796 3.4552183 3.2258487
#> [17,] 4.0329238 3.6529432 3.6776221 3.0133667 3.8305974 2.7167086 2.9761729
#> [18,] 2.3049527 2.3730463 3.7194718 2.7005356 3.1241534 2.3075488 1.7656046
#> [19,] 2.3049527 2.3730463 3.7194718 2.7005356 3.1241534 2.3075488 1.7656046
#> [20,] 3.1972414 2.1987935 1.7582984 2.4630865 3.3147070 2.8154827 2.4887827
#> [21,] 1.5361370 1.9174844 2.8209082 3.9157548 2.9121446 2.9773147 2.4243065
#> [22,] 1.8552079 3.1040041 3.4483219 3.3866531 2.8830250 1.5674202 1.8706235
#> [23,] 5.2658894 3.0834480 2.5561924 2.9833376 2.3292696 4.0645458 2.3826652
#> [24,] 5.3459789 3.0967957 2.7030238 2.8989695 2.1957873 4.1646574 2.6429565
#> [25,] 7.7035835 8.0528898 6.9377591 4.9728153 3.2345971 4.2876046 4.6351509
#> [26,] 8.2932518 6.9143991 8.0122945 7.6151836 7.4750264 5.6529872 3.3217147
#> [27,] 1.2097578 1.6348683 1.5289547 2.0332867 2.6851688 3.2047415 3.0192091
#> [28,] 2.7446332 2.8593194 4.4841880 7.4867582 7.1219489 6.6309999 4.4114229
#> [,42] [,43] [,44] [,45] [,46] [,47] [,48]
#> [1,] 1.8984363 1.3193317 0.9797313 0.88356130 2.122138 1.3794378 2.5304714
#> [2,] 4.4723866 2.8751081 2.3334195 1.98618378 3.541798 3.7640289 3.2640108
#> [3,] 3.4778432 4.4698049 3.3610766 3.86028552 1.649285 0.8210705 2.1930716
#> [4,] 1.7409927 0.1927155 0.8351030 0.09439127 1.167001 1.2526503 0.7341532
#> [5,] 1.4325744 1.3507123 1.2081339 1.42802761 1.609940 1.1360076 1.2415633
#> [6,] 1.5417200 1.5417200 1.5417200 1.02781999 1.027820 1.2847700 1.5417200
#> [7,] 0.6135766 2.2736527 2.1496391 1.47631625 1.479433 1.8126925 3.8135722
#> [8,] 2.6886167 3.6592738 3.1899917 2.01848098 3.894556 2.7324858 3.1887060
#> [9,] 0.5139080 0.6127373 0.8766694 0.45461163 1.692872 0.9981685 0.5743683
#> [10,] 3.2660200 4.0909780 5.6191766 5.49746449 7.505763 6.5658512 5.2058216
#> [11,] 1.5417200 1.5417200 1.5417200 1.54172003 1.541720 1.5417200 1.5417200
#> [12,] 1.4856611 2.8872275 2.7503598 2.51347712 2.840510 2.9406948 3.8683260
#> [13,] 1.3559371 0.7638116 0.6341497 0.55186828 3.283021 7.0009149 8.0369319
#> [14,] 0.2801036 0.2708434 1.1845235 2.06026024 2.148227 2.5116670 2.8241790
#> [15,] 2.5087678 2.5268414 2.2633359 1.34477138 1.899969 1.3574653 1.9733515
#> [16,] 2.1043051 2.4603318 2.7458117 2.15613989 3.282712 7.3009579 10.0885343
#> [17,] 2.5087678 2.5268414 2.2633359 1.34477138 1.899969 1.3574653 1.9733515
#> [18,] 1.8571910 2.6148837 3.3022412 2.75595738 3.119068 2.2470867 2.6763926
#> [19,] 1.8571910 2.6148837 3.3022412 2.75595738 3.119068 2.2470867 2.6763926
#> [20,] 2.3162565 3.2559729 5.5942557 4.28746179 4.647197 4.6325127 5.4233699
#> [21,] 1.6255135 1.7682841 2.0947324 3.45212133 3.271329 2.6365718 2.7929791
#> [22,] 2.0042400 3.1759513 3.1605345 2.69287843 2.790521 2.4616189 2.3609240
#> [23,] 1.5817685 2.7163715 3.1101446 4.51171173 2.963314 4.1780045 2.5094716
#> [24,] 1.3967752 2.6763265 2.9633139 4.65186823 3.017563 4.2247236 2.3559666
#> [25,] 4.5697504 4.3279104 4.2825674 3.00787401 2.774106 3.1892513 3.1388708
#> [26,] 4.0505294 4.6205000 4.6205000 4.33757090 4.106593 2.7143695 2.5228209
#> [27,] 3.2207035 3.3036945 5.3671278 5.67213945 8.107621 7.0726595 8.0788914
#> [28,] 3.2645615 2.5740880 2.0963818 1.24838686 1.693404 1.7645681 2.4359681
#> [,49] [,50] [,51] [,52] [,53] [,54] [,55]
#> [1,] 2.0255779 1.8470454 1.7821483 1.9865092 2.9782630 5.6257812 6.3532256
#> [2,] 2.4445349 3.8056964 3.5279113 2.8056608 3.4306839 3.1806735 1.5833884
#> [3,] 3.0057647 2.3568870 3.0953991 2.1751457 2.7880988 2.4440497 3.4718675
#> [4,] 1.9164461 0.9528725 1.4578190 1.7130269 3.7044217 3.8595537 3.1583932
#> [5,] 0.4147342 0.4320471 0.4547874 1.0323233 0.8004237 1.5826545 1.1405161
#> [6,] 1.5417200 1.5417200 1.5417200 1.5417200 1.5417200 1.5417200 2.5695400
#> [7,] 2.8187067 1.9310481 0.9343778 0.5765808 0.5606278 1.7099128 2.3577475
#> [8,] 6.0164859 5.2505308 3.1205964 5.5401799 3.8264492 2.9643714 1.8265383
#> [9,] 1.0772335 1.5820288 1.7393777 1.4330112 1.7533310 1.9568011 1.5417235
#> [10,] 7.7762451 6.5928978 4.9024110 5.3148900 4.4831712 5.6935589 3.2389734
#> [11,] 1.5417200 1.2847700 1.0278200 1.0278200 1.0278200 1.0278200 1.0278200
#> [12,] 3.1500654 2.0089136 3.0367282 4.1017478 2.1490689 3.2983560 1.9033641
#> [13,] 7.7110673 4.0400025 2.4183959 1.1209108 2.0663180 0.9145018 0.8908163
#> [14,] 3.5047593 5.5812265 4.7802697 6.7896037 5.1782571 4.0950610 3.4769809
#> [15,] 2.8119807 2.2754136 1.8528641 1.3912847 1.9607106 2.3093039 2.0824921
#> [16,] 5.3329655 3.3859156 2.7074137 4.5321236 4.4620731 3.7395537 3.1535994
#> [17,] 2.8119807 2.2754136 1.8528641 1.3912847 1.9607106 2.3093039 2.0824921
#> [18,] 1.8692131 4.0807333 5.3506892 5.3527848 3.6729320 5.0881981 4.6150945
#> [19,] 1.8692131 4.0807333 5.3506892 5.3527848 3.6729320 5.0881981 4.6150945
#> [20,] 5.9906991 6.0787996 5.8879176 4.6288421 3.7405167 2.9109217 3.3587561
#> [21,] 2.4745784 2.5529622 1.8768803 4.0721608 4.8020008 6.2506855 3.7146620
#> [22,] 2.3125845 4.1112631 6.2696775 4.4710005 3.8543105 5.2418621 4.4709986
#> [23,] 3.1768853 4.6852396 5.2725622 6.3404255 5.5528765 8.2091836 7.9889370
#> [24,] 3.2102556 4.4604585 5.3860223 6.3404255 5.4994838 8.2225316 7.9555666
#> [25,] 1.5971456 2.5896934 4.3707125 3.1187165 3.0884854 3.2245201 4.7662448
#> [26,] 3.8216076 1.8670425 2.4761021 3.6113719 3.6113718 3.4665421 2.7345556
#> [27,] 7.2107722 4.6666675 3.6899225 4.4966951 4.7017790 3.4122221 2.5374206
#> [28,] 3.3949751 2.8480014 3.4336334 5.2658595 7.8973593 7.5184526 7.5630897
#> [,56] [,57] [,58] [,59] [,60] [,61] [,62]
#> [1,] 4.420812 3.0263467 3.9903447 3.771665 4.0150940 3.8828615 3.3101727
#> [2,] 1.986183 2.4723138 2.8056609 3.791807 4.5835030 6.7641386 4.6251701
#> [3,] 3.172052 3.3762557 2.5874659 2.705401 3.5196729 2.5217344 4.2234958
#> [4,] 2.359781 4.5502259 3.4902919 3.817603 4.3575112 2.4410625 1.6780655
#> [5,] 1.223373 1.4741044 1.3370706 2.314858 0.3516218 0.2592288 0.6366993
#> [6,] 3.597360 3.5973599 3.5973599 3.597360 3.5973599 3.5973599 3.5973599
#> [7,] 1.877017 1.8843298 1.0402752 0.795932 0.9904427 0.3021159 0.8253687
#> [8,] 1.153160 0.2414757 0.7058503 2.018029 2.7924407 1.6419963 2.6252657
#> [9,] 1.966688 1.8843306 1.0772335 1.602182 2.2928204 1.9963360 2.1664753
#> [10,] 3.076687 3.3201165 3.5770695 1.710771 2.5357300 2.6844937 1.4605819
#> [11,] 1.027820 1.0278200 0.5139080 0.513908 0.5139080 0.5139080 0.5139080
#> [12,] 2.298569 1.8367424 2.7190411 4.316825 1.9794972 2.4761019 2.8778851
#> [13,] 1.347051 1.2784927 0.8982071 1.200170 1.8704433 1.1775129 0.6031285
#> [14,] 3.069559 2.9908526 2.3403652 2.266287 2.0996148 1.9699826 0.9540719
#> [15,] 2.562413 2.5718182 2.2131876 1.912282 1.9688032 2.3220071 1.5036114
#> [16,] 2.774029 2.5494468 1.7552907 1.614803 2.5166410 1.6242953 2.0557009
#> [17,] 2.562413 2.5718182 2.2131876 1.912282 1.9688032 2.3220071 1.5036114
#> [18,] 4.604819 6.2025135 5.9905554 6.217780 6.0510160 5.4392834 4.8166277
#> [19,] 4.604819 6.2025135 5.9905554 6.217780 6.0510160 5.4392834 4.8166277
#> [20,] 4.239741 4.7096003 7.0735826 10.384623 7.0809190 5.2712291 5.9172832
#> [21,] 4.133608 5.2219688 4.6084132 4.893298 6.2884662 5.9602155 6.2897893
#> [22,] 4.753649 6.2439824 5.9613330 6.526634 5.8071615 5.3446426 4.8050395
#> [23,] 9.584060 9.9911711 6.6007150 6.754220 6.6140634 8.3827184 9.5640418
#> [24,] 9.363813 10.2514624 6.5490334 6.720849 6.7275238 8.2492355 9.5863745
#> [25,] 5.613073 5.7436794 7.6380867 8.202378 11.0994100 6.4063877 6.9579123
#> [26,] 4.606484 5.6950350 5.6529896 7.792716 8.8401686 9.6474554 6.7976013
#> [27,] 3.495214 1.9432147 3.7888746 3.507980 2.9260629 5.2124957 6.1541292
#> [28,] 4.276529 4.4682707 4.6342275 3.024326 3.2555055 2.0351667 3.9686374
#> [,63] [,64] [,65] [,66] [,67] [,68] [,69]
#> [1,] 5.8032540 6.9602990 4.7754370 3.6215397 3.8227549 4.4839219 4.9767934
#> [2,] 4.4168309 4.6390596 5.6113195 6.0557811 6.6391357 5.7224351 4.9307382
#> [3,] 3.0535710 3.3284508 5.1036380 4.6251730 6.8899537 4.1585197 4.2427288
#> [4,] 2.2697592 1.7344363 1.5836739 1.7772642 3.0727436 0.9648874 1.1991187
#> [5,] 0.6897190 1.2688532 0.2840018 0.9505013 0.5002650 0.7302915 0.7003711
#> [6,] 3.5973599 3.5973599 3.5973599 3.5973599 3.5973599 3.5973599 3.5973599
#> [7,] 1.7924108 2.1148087 1.6881095 1.4576295 1.1030215 0.8097947 0.9810979
#> [8,] 0.2444200 1.3250167 0.8606423 1.3537087 0.9473245 0.8836727 1.6531750
#> [9,] 1.6603182 3.1136780 2.0753958 2.6602300 2.4608306 2.5796173 1.0377000
#> [10,] 2.0285846 3.0631614 2.1570596 1.7716295 3.2254483 2.0150616 2.2652535
#> [11,] 0.0000000 0.0000000 0.0000000 0.0000000 0.0000000 1.0278200 1.0278200
#> [12,] 3.1215174 4.6251727 2.2078996 2.4387265 2.7657602 3.7020403 1.0651914
#> [13,] 0.9612445 1.9786828 1.0508440 1.0898957 1.5951510 0.8937895 0.8492480
#> [14,] 0.9838323 0.6250242 0.8310499 1.3912546 1.6574679 1.6574684 1.6921923
#> [15,] 2.0727007 2.5877660 2.9397811 3.5743386 3.8932425 3.7040715 4.2255368
#> [16,] 2.3353637 2.3377992 1.9846791 1.9808649 2.2293758 3.2542695 3.7989480
#> [17,] 2.0727007 2.5877660 2.9397811 3.5743386 3.8932425 3.7040715 4.2255368
#> [18,] 4.5895544 3.2245217 2.4168937 2.3075471 4.2028522 5.6227592 4.1621466
#> [19,] 4.5895544 3.2245217 2.4168937 2.3075471 4.2028522 5.6227592 4.1621466
#> [20,] 7.1580064 9.0594708 7.1029435 5.3079353 4.6875746 8.0279826 7.8701419
#> [21,] 5.9937328 5.7358764 4.9938446 4.0386455 3.7410305 3.7593485 1.2065666
#> [22,] 4.6251720 3.1862305 2.3896718 2.2611946 4.2911325 5.4731210 4.3168280
#> [23,] 6.5606697 6.5006025 5.8465373 7.1012747 9.9911869 8.7231003 9.2703763
#> [24,] 6.5606697 6.5272990 5.8331890 7.0892956 9.9911869 8.7231003 9.2703763
#> [25,] 6.7211153 9.8196872 6.5246166 6.0371710 6.9730268 10.0917619 8.6205622
#> [26,] 6.5640073 9.0167636 7.5624662 6.1295207 6.4612249 9.7455788 8.7130854
#> [27,] 8.2578631 9.1801244 7.0662353 8.3151058 6.9872348 6.1925913 9.3333483
#> [28,] 2.9379159 5.8408935 7.5426260 8.6594655 7.3925485 7.2830087 7.8382397
#> [,70] [,71] [,72] [,73] [,74] [,75] [,76]
#> [1,] 2.9241656 3.1862295 2.6466260 2.7494083 2.5438453 1.6702005 1.259074
#> [2,] 4.0557049 2.8213566 2.2303610 3.3969332 3.4586002 7.1433260 7.312911
#> [3,] 6.1429931 5.2983913 6.9274802 6.0589745 4.4966960 3.9725093 3.160533
#> [4,] 3.4819883 2.6157939 2.6569032 2.1224383 3.4072096 3.2581776 3.196509
#> [5,] 0.6942262 0.3905696 1.1511548 1.6804817 1.6496438 1.2487955 2.430785
#> [6,] 3.5973599 2.3125866 2.7237119 3.2376190 4.1112630 4.9849085 3.777225
#> [7,] 0.6696381 1.2333797 1.0021204 1.7472879 1.3875500 1.9785440 2.132717
#> [8,] 0.8544504 0.4882136 0.6423864 0.3083448 0.4882130 1.5417244 1.361856
#> [9,] 0.8993404 4.0033435 2.6671819 2.5541220 3.0577527 3.7258314 3.859449
#> [10,] 1.6685314 1.8757625 0.6166891 0.8479502 1.2076835 0.4882128 0.436822
#> [11,] 1.0278200 2.2714725 2.3999511 2.8933016 4.2243232 5.6735444 7.169018
#> [12,] 2.4854457 2.3485587 2.6466265 3.1862285 3.1091455 3.2119255 2.477036
#> [13,] 0.6662180 0.2312586 0.5396046 0.7194728 0.5909948 0.0513908 0.000000
#> [14,] 1.5070013 1.6702012 2.1584130 2.5952360 2.6980160 2.8007999 4.342523
#> [15,] 4.2976799 3.3301239 2.8059380 3.0577524 2.6106519 3.2633171 5.056854
#> [16,] 4.2500206 3.3301239 2.8059380 3.0577524 2.6106519 3.2633171 5.056854
#> [17,] 4.2976799 3.3301239 2.8059380 3.0577524 2.6106519 3.2633171 5.056854
#> [18,] 4.9224329 9.1578484 11.4447455 6.6037185 6.5420502 5.5964594 5.575901
#> [19,] 4.9224329 9.1578484 11.4447455 6.6037185 6.5420502 5.5964594 5.575901
#> [20,] 8.0002039 8.5771343 7.9758592 9.2914705 8.6696369 10.4888725 8.582268
#> [21,] 3.9731168 3.4688795 5.8585520 4.2397410 6.0384221 9.7642600 10.226781
#> [22,] 4.6913189 8.9728415 11.4396065 6.8246990 6.6653882 5.4679823 5.755769
#> [23,] 9.6908422 9.4405012 6.0949489 8.0323845 8.2842024 10.5145700 8.309897
#> [24,] 9.6908422 9.4405012 6.0949489 8.0323845 8.2842024 10.5145700 8.309897
#> [25,] 9.5576862 9.4405012 6.0949489 8.0323845 8.2842024 10.5145700 8.309897
#> [26,] 9.5945280 9.4405012 6.0949489 8.0323845 8.2842024 10.5145700 8.309897
#> [27,] 9.4077359 9.4405012 6.0949489 8.0323845 8.2842024 10.5145700 8.309897
#> [28,] 9.1935046 9.4405012 6.0949489 8.0323845 8.2842024 10.5145700 8.309897
#> [,77] [,78] [,79] [,80] [,81] [,82] [,83]
#> [1,] 0.7451666 0.8993390 0.8479502 0.9507320 1.002123 0.7194715 0.9764253
#> [2,] 7.8319625 7.2255500 7.5184755 9.1938208 11.007925 6.9069251 8.1300262
#> [3,] 1.8603442 4.7330936 4.0752905 5.3960338 4.707398 3.6281906 2.0299350
#> [4,] 3.2273428 3.0269181 3.1091445 2.5541222 1.546863 0.8582253 2.0967436
#> [5,] 1.3310216 2.3948106 2.3793941 2.3845346 1.978546 2.2663349 1.4749141
#> [6,] 3.1862285 3.7515276 4.1883505 3.6230510 1.695895 0.5396052 0.2312586
#> [7,] 1.5674190 1.2847679 2.0813277 1.5674184 1.438942 1.0278161 0.6937752
#> [8,] 2.3382814 2.4924525 1.5417237 2.0042420 0.925033 0.7451666 0.9250337
#> [9,] 3.7669443 2.4153670 1.5571423 2.6980175 2.528427 2.4924535 2.0967433
#> [10,] 0.1027816 0.7965596 0.3340404 0.6680816 1.464638 1.8757646 0.5652994
#> [11,] 6.1668960 6.6756692 6.7835855 5.1956088 4.825596 5.4474245 3.2067861
#> [12,] 1.7935372 1.0997622 0.4676566 0.8530880 1.053511 2.2817527 1.7215920
#> [13,] 0.0000000 0.6937768 1.3104652 0.8222538 1.130597 0.5909948 0.9764260
#> [14,] 2.8778845 2.9806670 4.4453045 3.2376215 2.543843 1.9528495 2.9292760
#> [15,] 2.9549714 1.6239481 3.1862310 1.7113128 2.698018 3.6230520 3.3044284
#> [16,] 2.9549714 1.6239481 3.1862310 1.7113128 2.698018 3.6230520 3.3044284
#> [17,] 2.9549714 1.6239481 3.1862310 1.7113128 2.698018 3.6230520 3.3044284
#> [18,] 7.6315367 6.9428985 9.2452134 7.0405412 6.418710 5.1956096 3.9725083
#> [19,] 7.6315367 6.9428985 9.2452134 7.0405412 6.418710 5.1956096 3.9725083
#> [20,] 6.5934403 8.8135329 8.3253111 8.6542193 10.103439 8.4332396 8.4332330
#> [21,] 6.8863675 5.6529900 5.9356380 5.6786830 7.580146 8.1968389 7.8884914
#> [22,] 7.4516689 6.7116400 9.4559155 6.9017858 6.670525 5.1031062 4.1164027
#> [23,] 8.6285209 8.9471488 6.2645391 8.6799104 10.041771 8.8340859 9.4148095
#> [24,] 8.6285209 8.9471488 6.2645391 8.6799104 10.041771 8.8340859 9.4148095
#> [25,] 8.6285209 8.9471488 6.2645391 8.6799104 10.041771 8.8340859 9.4148095
#> [26,] 8.6285209 8.9471488 6.2645391 8.6799104 10.041771 8.8340859 9.4148095
#> [27,] 8.6285209 8.9471488 6.2645391 8.6799104 10.041771 8.8340859 9.4148095
#> [28,] 8.6285209 8.9471488 6.2645391 8.6799104 10.041771 8.8340859 9.4148095
#> [,84] [,85] [,86] [,87] [,88] [,89] [,90]
#> [1,] 1.2333792 1.3875503 2.1841075 1.8500669 2.2868895 2.3639765 1.9271544
#> [2,] 7.4311167 9.2349396 10.3963772 10.0777446 9.1989629 10.7766536 10.2576251
#> [3,] 2.8778847 4.8667077 3.4534607 4.8512922 3.3660990 2.9344156 2.0402153
#> [4,] 2.3845329 2.7699625 2.4975911 2.2098027 2.2252215 1.4800554 1.4903334
#> [5,] 1.8654862 2.1481350 2.0299381 3.2273417 3.2735929 3.5562420 4.3373838
#> [6,] 0.2055632 1.0535116 1.4132476 1.5674180 1.2847701 1.8500685 1.5417243
#> [7,] 0.7965594 0.6423868 0.5652996 1.3104648 1.8500665 1.7729837 1.3875505
#> [8,] 0.5909958 0.7965596 0.8479490 0.9507314 1.3875505 0.6166902 0.5653000
#> [9,] 2.7596857 1.6085326 1.3515770 1.2231000 0.5036310 0.5550222 0.2261196
#> [10,] 0.6937772 1.1305986 1.6188103 0.9250346 1.5931140 2.9292770 4.3168260
#> [11,] 3.0526144 3.8491704 2.0196570 2.1635523 2.0453555 2.1378575 2.7596847
#> [12,] 2.3948113 2.1686902 1.6496421 2.1018834 1.7267296 1.6958967 2.1738315
#> [13,] 0.8736436 1.6958945 2.4667585 2.3639760 1.3618578 2.1070226 2.8008000
#> [14,] 1.3618560 1.3104660 1.4132469 0.8736434 0.8736454 1.0021197 1.1562917
#> [15,] 3.3301232 2.7288502 2.0402160 1.7472865 3.6127719 2.6260701 3.3044293
#> [16,] 3.3301232 2.7288502 2.0402160 1.7472865 3.6127719 2.6260701 3.3044293
#> [17,] 3.3301232 2.7288502 2.0402160 1.7472865 3.6127719 2.6260701 3.3044293
#> [18,] 6.9685918 7.6880724 8.8752022 7.7034856 8.6388026 7.5544521 9.8105203
#> [19,] 6.9685918 7.6880724 8.8752022 7.7034856 8.6388026 7.5544521 9.8105203
#> [20,] 5.9818895 8.9368679 9.8464850 8.6799140 9.8208014 7.6880650 5.8174384
#> [21,] 7.5801440 5.6529875 5.3703380 4.4966950 7.4773629 7.6829340 8.1454500
#> [22,] 6.7578894 7.8165492 8.8495067 7.6161216 8.6490804 7.2718011 10.0417807
#> [23,] 8.4537963 8.0221112 9.1321540 6.9120660 8.0786419 8.1865623 5.4679805
#> [24,] 8.4537963 8.0221112 9.1321540 6.9120660 8.0786419 8.1865623 5.4679805
#> [25,] 8.4537963 8.0221112 9.1321540 6.9120660 8.0786419 8.1865623 5.4679805
#> [26,] 8.4537963 8.0221112 9.1321540 6.9120660 8.0786419 8.1865623 5.4679805
#> [27,] 8.4537963 8.0221112 9.1321540 6.9120660 8.0786419 8.1865623 5.4679805
#> [28,] 8.4537963 8.0221112 9.1321540 6.9120660 8.0786419 8.1865623 5.4679805
#> [,91] [,92] [,93] [,94] [,95]
#> [1,] 1.5931133 2.6466270 4.445304 3.8286141 4.3939115
#> [2,] 8.3767037 5.4628427 3.962230 5.0671331 3.6076342
#> [3,] 2.9806675 3.0166399 3.340403 2.1841097 2.6003746
#> [4,] 1.3978296 1.6342290 1.495473 1.6239473 1.0483737
#> [5,] 4.1266834 4.0907066 2.662042 4.4453045 4.3014102
#> [6,] 1.0792058 0.5653004 0.745168 1.6958945 1.4132475
#> [7,] 2.4153669 4.1112630 3.109143 3.5459640 3.4174880
#> [8,] 1.2076850 1.8757625 2.261194 2.6209310 1.3618572
#> [9,] 0.7554464 2.3331424 2.574679 3.6436080 5.0774106
#> [10,] 3.0320565 4.3425230 2.029934 1.3618547 2.9035795
#> [11,] 2.1275790 2.8110756 1.850070 2.0350763 2.0761871
#> [12,] 2.3896725 2.4462016 2.245778 1.3978304 3.5665221
#> [13,] 2.5952369 2.2354985 1.798678 1.4132471 0.6937774
#> [14,] 0.9507308 0.5139086 0.462518 0.8222546 0.0770862
#> [15,] 2.4153684 1.7318702 1.824375 2.0659096 2.2714727
#> [16,] 2.4153684 1.7318702 1.824375 2.0659096 2.2714727
#> [17,] 2.4153684 1.7318702 1.824375 2.0659096 2.2714727
#> [18,] 8.0426665 11.1364006 8.602823 7.4156951 7.7086260
#> [19,] 8.0426665 11.1364006 8.602823 7.4156951 7.7086260
#> [20,] 6.5214923 8.9265924 7.831967 6.8863680 6.8298373
#> [21,] 8.2996210 8.7364450 7.914190 9.2246610 8.3767090
#> [22,] 8.1043357 10.9513934 8.695327 7.5595892 7.3900010
#> [23,] 5.2110271 4.9643506 7.975853 6.7733088 9.1886832
#> [24,] 5.2110271 4.9643506 7.975853 6.7733088 9.1886832
#> [25,] 5.2110271 4.9643506 7.975853 6.7733088 9.1886832
#> [26,] 5.2110271 4.9643506 7.975853 6.7733088 9.1886832
#> [27,] 5.2110271 4.9643506 7.975853 6.7733088 9.1886832
#> [28,] 5.2110271 4.9643506 7.975853 6.7733088 9.1886832
# Heatmaps with multiple bigWig
h <- bw_heatmap(c(bw, bw2), loci = bed, mode = "stretch")
# h is a list
h[[2]]
#> [,1] [,2] [,3] [,4] [,5] [,6] [,7]
#> [1,] 0.3942086 0.7095757 0.48181045 0.47305026 0.6657744 0.16644361 0.0000000
#> [2,] 0.4380095 0.3942086 0.00000000 0.37668817 0.4117289 0.11388247 0.2803261
#> [3,] 0.0000000 0.0000000 0.00000000 0.07008152 0.3241270 0.11388247 0.2803261
#> [4,] 0.0000000 0.0000000 0.00000000 0.00000000 1.2264277 0.36792810 0.8146979
#> [5,] 0.3153668 0.8760196 0.03504076 0.00000000 0.0000000 0.00000000 0.0000000
#> [6,] 0.4818108 0.7008158 0.00000000 1.27022905 0.3942086 0.04380095 1.4454325
#> [7,] 0.0000000 0.0000000 0.00000000 0.00000000 0.3942086 0.39420855 0.0000000
#> [8,] 0.2277649 0.0000000 0.00000000 0.00000000 0.0000000 0.78841781 0.6920553
#> [9,] 0.6394939 0.3942086 0.39420855 0.00000000 0.3942086 0.39420855 0.4380095
#> [10,] 0.0000000 0.1138825 0.91982015 0.55189213 1.4016316 0.25404555 0.0000000
#> [11,] 0.0000000 0.0000000 0.00000000 0.00000000 0.4380095 0.39420855 0.7884179
#> [12,] 0.3942086 0.0000000 0.00000000 0.00000000 0.0000000 0.13140285 0.2628057
#> [13,] 0.4380095 0.3942086 0.00000000 0.39420855 0.6657744 0.13140285 0.3854484
#> [14,] 0.0000000 0.0000000 0.39420855 0.00000000 0.0000000 0.39420855 0.0000000
#> [15,] 0.0000000 0.0000000 0.00000000 0.01752038 0.3766882 0.00000000 0.0000000
#> [16,] 0.0000000 0.0000000 0.00000000 0.00000000 0.4204891 0.01752038 0.3942086
#> [17,] 0.0000000 0.0000000 0.00000000 0.01752038 0.3766882 0.00000000 0.0000000
#> [18,] 0.0000000 0.0000000 0.00000000 0.00000000 0.0000000 0.00000000 0.0000000
#> [19,] 0.0000000 0.0000000 0.00000000 0.00000000 0.0000000 0.00000000 0.0000000
#> [20,] 0.0000000 0.0000000 0.00000000 0.00000000 0.0000000 0.00000000 0.0000000
#> [21,] 0.0000000 0.0000000 0.00000000 0.00000000 0.0000000 0.00000000 0.0000000
#> [22,] 0.0000000 0.0000000 0.00000000 0.00000000 0.0000000 0.00000000 0.0000000
#> [23,] 0.0000000 0.4642901 0.36792798 0.00000000 0.0000000 0.63949387 0.5869328
#> [24,] 0.0000000 0.3679280 0.46429007 0.00000000 0.0000000 0.54313178 0.6832949
#> [25,] 0.0000000 0.2452855 0.58693336 1.22642784 0.7708976 0.53437161 0.7533767
#> [26,] 0.0000000 0.8322187 0.47305050 0.31536690 0.0000000 0.83221886 0.5781731
#> [27,] 0.0876019 0.3942086 0.30660665 0.00000000 0.3942086 0.00000000 0.3942086
#> [28,] 0.0000000 0.0000000 0.00000000 0.00000000 0.0000000 0.43800950 0.1839640
#> [,8] [,9] [,10] [,11] [,12] [,13] [,14]
#> [1,] 0.00000000 0.0000000 0.00000000 0.09636209 0.29784646 0.3942086 0.0000000
#> [2,] 0.00000000 0.0000000 0.39420855 0.00000000 0.28908627 0.2628057 0.6307341
#> [3,] 0.00000000 0.0000000 0.00000000 0.00000000 0.00000000 0.0000000 0.2890863
#> [4,] 0.00000000 0.1401630 1.13882541 1.22642741 0.87601951 0.5606522 0.0000000
#> [5,] 0.05256114 0.3854484 0.00000000 0.39420855 0.00000000 0.1401630 0.4380095
#> [6,] 0.96362121 0.7446165 0.39420855 0.39420855 0.00000000 0.0000000 0.0000000
#> [7,] 0.00000000 0.0000000 0.39420855 0.39420855 0.00000000 0.0000000 0.0000000
#> [8,] 0.49057074 0.3942086 0.00000000 0.00000000 0.00000000 0.0000000 0.0000000
#> [9,] 0.39420855 0.0000000 0.00000000 0.00000000 0.00000000 0.0000000 0.0000000
#> [10,] 0.00000000 0.0000000 0.00000000 0.00000000 0.00000000 0.0000000 0.4380095
#> [11,] 1.13882541 1.2702287 0.00000000 0.65701471 0.96362141 0.0000000 0.0000000
#> [12,] 0.39420855 0.0000000 0.00000000 0.00000000 0.00000000 0.0000000 0.0000000
#> [13,] 0.00000000 0.0000000 0.00000000 0.00000000 0.00000000 0.2277649 0.4818105
#> [14,] 0.00000000 0.0000000 0.00000000 0.00000000 0.00000000 0.0000000 0.0000000
#> [15,] 0.39420855 0.0000000 0.00000000 0.00000000 0.28032608 0.1138825 0.3942086
#> [16,] 0.00000000 0.0000000 0.00000000 0.43800950 0.00000000 0.2890863 0.1051223
#> [17,] 0.39420855 0.0000000 0.00000000 0.00000000 0.28032608 0.1138825 0.3942086
#> [18,] 0.00000000 0.0000000 0.01752038 0.37668817 0.14892323 0.2452853 0.0000000
#> [19,] 0.00000000 0.0000000 0.01752038 0.37668817 0.14892323 0.2452853 0.0000000
#> [20,] 0.00000000 0.0000000 0.01752038 0.37668817 0.14892323 0.2452853 0.0000000
#> [21,] 0.00000000 0.0000000 0.32412703 0.07008152 0.39420855 0.0000000 0.0000000
#> [22,] 0.00000000 0.0000000 0.39420855 0.00000000 0.39420855 0.0000000 0.0000000
#> [23,] 0.00000000 0.3942086 0.00000000 0.00000000 0.00000000 0.0000000 0.0000000
#> [24,] 0.00000000 0.3241270 0.07008152 0.00000000 0.00000000 0.0000000 0.0000000
#> [25,] 0.00000000 0.3854484 0.00876019 1.17386637 0.00876019 0.1664436 0.6657744
#> [26,] 0.68329557 1.1651061 0.78841751 0.07008152 0.01752038 0.3766882 0.7796578
#> [27,] 0.00000000 0.0000000 0.00000000 0.00000000 0.00000000 0.0000000 0.3942086
#> [28,] 0.64825406 0.1401630 0.25404551 0.39420855 0.39420855 0.0000000 0.0000000
#> [,15] [,16] [,17] [,18] [,19] [,20] [,21]
#> [1,] 0.00000000 0.0000000 0.00000000 0.0000000 0.00000000 0.0000000 0.0000000
#> [2,] 0.00000000 0.4380095 0.00000000 0.0000000 0.00000000 0.4380095 0.0000000
#> [3,] 0.10512228 0.0000000 0.24528532 0.1489232 0.00000000 0.0000000 0.0000000
#> [4,] 0.00000000 0.0000000 0.00876019 0.3854484 0.00000000 0.3942086 0.0000000
#> [5,] 0.30660665 0.6920550 0.00000000 0.0000000 0.00000000 0.0000000 0.0000000
#> [6,] 0.00000000 0.0000000 0.39420855 0.4380095 1.83964175 0.1314029 1.7958408
#> [7,] 0.01752038 0.7008152 0.11388247 0.8322182 0.23652513 0.1576834 0.0000000
#> [8,] 0.00000000 0.0000000 0.00000000 0.0000000 0.00000000 0.3942086 0.3416474
#> [9,] 0.00000000 0.0000000 0.00000000 0.7884174 0.14892323 0.6394939 0.0000000
#> [10,] 0.37668817 0.8059383 1.12130503 1.2877491 0.00000000 0.6219739 0.9986622
#> [11,] 0.00000000 0.0000000 0.00000000 0.0000000 0.00000000 0.0000000 0.0000000
#> [12,] 0.00000000 0.0000000 0.00000000 0.0000000 0.00000000 0.0000000 0.0000000
#> [13,] 0.16644361 0.7884176 0.00000000 0.0000000 0.00000000 0.0000000 0.0000000
#> [14,] 0.00000000 0.0000000 0.00000000 0.3942086 0.39420855 0.0000000 0.0000000
#> [15,] 0.00000000 0.0000000 0.00000000 0.0000000 0.00000000 0.3942086 0.3942086
#> [16,] 0.00000000 0.0000000 0.00000000 0.0000000 0.00000000 0.0000000 0.0000000
#> [17,] 0.00000000 0.0000000 0.00000000 0.0000000 0.00000000 0.3942086 0.3942086
#> [18,] 0.00000000 0.0000000 0.00000000 0.0000000 0.00000000 0.0000000 0.0000000
#> [19,] 0.00000000 0.0000000 0.00000000 0.0000000 0.00000000 0.0000000 0.0000000
#> [20,] 0.00000000 0.0000000 0.00000000 0.0000000 0.00000000 0.0000000 0.0000000
#> [21,] 0.00000000 0.0000000 0.00000000 0.0000000 0.00000000 0.0000000 0.0000000
#> [22,] 0.00000000 0.0000000 0.00000000 0.0000000 0.00000000 0.0000000 0.0000000
#> [23,] 0.00000000 0.7884180 0.15768342 0.5694124 0.06132133 0.0000000 0.0000000
#> [24,] 0.00000000 0.6482548 0.20148453 0.5694124 0.15768342 0.0000000 0.0000000
#> [25,] 0.00000000 0.0000000 0.39420855 0.8322182 0.00000000 0.1226427 0.2715659
#> [26,] 0.40296880 0.0000000 0.67453463 0.1576834 0.00000000 0.1489232 0.7446163
#> [27,] 0.00000000 0.3942086 0.00000000 0.0000000 0.00000000 0.0000000 0.0000000
#> [28,] 0.09636209 0.6920550 0.00000000 0.0000000 0.39420855 0.2277649 0.2102446
#> [,22] [,23] [,24] [,25] [,26] [,27] [,28]
#> [1,] 0.00000000 0.0000000 0.0000000 0.00000000 0.23188738 0.23053132 0.0000000
#> [2,] 0.39420855 0.8322181 0.0000000 0.00000000 0.00000000 0.00000000 0.0000000
#> [3,] 0.00000000 0.0000000 0.0000000 0.00000000 0.00000000 0.00000000 0.0000000
#> [4,] 0.00000000 0.0000000 0.0000000 0.00000000 0.00000000 0.00000000 0.0000000
#> [5,] 0.00000000 0.0000000 0.0000000 0.00876019 0.44963807 0.58918128 0.1613719
#> [6,] 1.66443774 0.7884173 0.9198205 0.04380095 0.00000000 0.00000000 0.0000000
#> [7,] 0.00000000 0.0000000 0.0000000 0.39420855 0.00000000 0.05840127 0.4194273
#> [8,] 0.05256114 0.0000000 0.0000000 0.00000000 0.48074213 0.09499001 0.3845937
#> [9,] 0.00000000 0.3942086 0.0000000 0.39420855 0.00000000 0.00000000 0.0000000
#> [10,] 0.00000000 0.0000000 0.0000000 0.00000000 0.00000000 0.00000000 0.0000000
#> [11,] 0.00000000 0.0000000 0.0000000 0.00000000 0.00000000 0.00000000 0.0000000
#> [12,] 0.00000000 0.0000000 0.0000000 0.00000000 0.00000000 0.00000000 0.0000000
#> [13,] 0.49057064 0.8847798 0.2452855 0.00876019 0.82790476 0.23227777 0.4562600
#> [14,] 0.00000000 0.0000000 0.0000000 0.00000000 0.00000000 0.00000000 0.2051936
#> [15,] 0.00000000 0.0000000 0.0000000 0.00000000 0.15702227 0.16559906 0.0000000
#> [16,] 0.00000000 0.0000000 0.0000000 0.00000000 0.07347783 0.00000000 0.0000000
#> [17,] 0.00000000 0.0000000 0.0000000 0.00000000 0.15702227 0.16559906 0.0000000
#> [18,] 0.00000000 0.0000000 0.0000000 0.00000000 0.00000000 0.00000000 0.0000000
#> [19,] 0.00000000 0.0000000 0.0000000 0.00000000 0.00000000 0.00000000 0.0000000
#> [20,] 0.00000000 0.0000000 0.0000000 0.00000000 0.00000000 0.00000000 0.0000000
#> [21,] 0.00000000 0.0000000 0.0000000 0.00000000 0.00000000 0.00000000 0.0000000
#> [22,] 0.00000000 0.0000000 0.0000000 0.00000000 0.00000000 0.00000000 0.0000000
#> [23,] 0.00000000 0.0000000 0.0000000 0.00000000 0.00000000 0.00000000 0.5005823
#> [24,] 0.00000000 0.0000000 0.0000000 0.00000000 0.00000000 0.00000000 0.3868136
#> [25,] 0.00000000 0.0000000 0.0000000 0.00000000 0.00000000 0.32636040 0.4465984
#> [26,] 0.33288722 0.0000000 0.3942086 0.00000000 0.00000000 0.00000000 0.0000000
#> [27,] 0.00000000 0.0000000 0.0000000 0.83221866 0.48970025 0.07617559 0.7227164
#> [28,] 0.00000000 0.0000000 0.0000000 0.00000000 0.00000000 0.00000000 0.2739971
#> [,29] [,30] [,31] [,32] [,33] [,34]
#> [1,] 0.00000000 0.48954003 0.46106287 0.00000000 0.00000000 0.23188738
#> [2,] 0.00000000 0.00000000 0.00000000 0.00000000 0.21308570 0.85234281
#> [3,] 0.00000000 0.45838204 0.00000000 0.00000000 0.45838204 0.45838204
#> [4,] 0.00000000 0.00000000 0.00000000 0.00000000 0.67526465 0.14302351
#> [5,] 0.18605713 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000
#> [6,] 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000
#> [7,] 0.00000000 0.00000000 0.00000000 0.00000000 0.24037107 0.39288125
#> [8,] 0.00000000 0.00000000 0.00000000 0.07388112 0.45937582 0.30607898
#> [9,] 0.00000000 0.00000000 0.69070729 0.06870737 0.48854906 0.26954431
#> [10,] 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000
#> [11,] 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000
#> [12,] 0.04778285 0.66895996 0.51912237 0.20705904 0.00000000 0.09556571
#> [13,] 0.00000000 0.15761723 0.29864292 0.49276078 1.44012349 0.80135884
#> [14,] 0.14994920 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000
#> [15,] 0.00000000 0.00000000 0.15731910 0.00000000 0.14903915 0.00000000
#> [16,] 0.07354637 0.07347783 0.18777672 0.00000000 0.03673891 0.07347783
#> [17,] 0.00000000 0.00000000 0.15731910 0.00000000 0.14903915 0.00000000
#> [18,] 0.00000000 0.00000000 0.00000000 0.38647897 0.00000000 0.42942108
#> [19,] 0.00000000 0.00000000 0.00000000 0.38647897 0.00000000 0.42942108
#> [20,] 0.00000000 0.28157754 0.07508734 0.23777659 0.00000000 0.00000000
#> [21,] 0.00000000 0.00000000 0.00000000 0.42388016 0.00000000 0.35231199
#> [22,] 0.00000000 0.00000000 0.39420855 0.00000000 0.25404551 0.18396399
#> [23,] 0.01137687 0.43232107 0.07963809 0.00000000 0.00000000 0.00000000
#> [24,] 0.12514557 0.32569937 0.18202992 0.00000000 0.00000000 0.00000000
#> [25,] 0.49812845 0.27482949 0.00000000 0.00000000 0.00000000 0.00000000
#> [26,] 0.00000000 0.33754900 0.39022709 0.59728568 0.11149333 0.00000000
#> [27,] 1.00116567 0.76175590 0.00000000 0.24485003 0.73914160 0.19588003
#> [28,] 0.08140000 0.33960208 0.00000000 0.00000000 0.06977142 0.20067396
#> [,35] [,36] [,37] [,38] [,39] [,40]
#> [1,] 0.23053132 0.00000000 0.00000000 0.00000000 0.48667776 0.461062988
#> [2,] 0.00000000 0.00000000 1.27851570 0.85234380 0.00000000 0.071028568
#> [3,] 0.37255981 0.59080363 0.00000000 0.31214470 0.14260774 0.000000000
#> [4,] 0.43800950 0.38325831 0.00000000 0.00000000 0.00000000 0.000000000
#> [5,] 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.348857124
#> [6,] 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.000000000
#> [7,] 0.13803936 0.23891427 0.24037107 0.26546030 0.00000000 0.265460303
#> [8,] 1.13241562 0.12665335 1.31402968 0.28497004 0.61215798 1.036266750
#> [9,] 0.00000000 0.06738608 0.70425057 0.00000000 0.00000000 0.336930385
#> [10,] 0.00000000 0.00000000 0.00000000 0.57632829 0.00000000 0.518695461
#> [11,] 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.000000000
#> [12,] 0.62117711 0.00000000 0.55746664 0.15927618 0.00000000 0.000000000
#> [13,] 0.54253480 0.44796443 0.23227794 0.22398213 0.07466071 0.232277938
#> [14,] 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.000000000
#> [15,] 0.07451957 0.00000000 0.45539754 0.10763939 0.34775802 0.074519575
#> [16,] 0.19203779 0.11429884 0.07347783 0.00000000 0.00000000 0.338814712
#> [17,] 0.07451957 0.00000000 0.45539754 0.10763939 0.34775802 0.074519575
#> [18,] 0.00000000 0.00000000 0.00000000 0.38647897 0.01734691 0.412244236
#> [19,] 0.00000000 0.00000000 0.00000000 0.38647897 0.01734691 0.412244236
#> [20,] 0.28157754 0.31286393 0.00000000 0.00000000 0.00000000 0.000000000
#> [21,] 0.12378529 0.00000000 0.00000000 0.00000000 0.42388016 0.009521946
#> [22,] 0.00000000 0.00000000 0.00000000 0.39420855 0.34164741 0.096362090
#> [23,] 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.000000000
#> [24,] 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.000000000
#> [25,] 0.00000000 0.00000000 0.00000000 0.06870737 0.31777160 0.386478971
#> [26,] 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.000000000
#> [27,] 0.32102560 0.00000000 0.76175572 0.00000000 0.24638034 0.000000000
#> [28,] 0.07752381 0.00000000 0.00000000 0.35117969 0.36436202 0.366616239
#> [,41] [,42] [,43] [,44] [,45] [,46]
#> [1,] 0.00000000 0.00000000 0.000000000 0.00000000 0.00000000 0.00000000
#> [2,] 0.87601900 0.23676189 0.000000000 0.00000000 0.00000000 0.00000000
#> [3,] 0.00000000 0.00000000 0.000000000 0.00000000 0.00000000 0.00000000
#> [4,] 0.00000000 0.00000000 0.000000000 0.00000000 0.00000000 0.00000000
#> [5,] 0.00000000 0.52716188 0.519409496 0.00000000 0.34885712 0.38761903
#> [6,] 0.00000000 0.00000000 0.000000000 0.00000000 0.00000000 0.00000000
#> [7,] 0.24037107 0.26546030 0.355716806 0.50210845 0.12742095 0.74328928
#> [8,] 0.08443557 0.07478211 0.928792085 0.02136632 0.66493009 0.26386114
#> [9,] 0.42942108 0.00000000 0.000000000 0.00000000 0.00000000 0.00000000
#> [10,] 0.04610626 0.53022203 0.000000000 0.42648293 0.09221253 0.00000000
#> [11,] 0.00000000 0.00000000 0.438009501 0.87601900 0.87601900 0.87601900
#> [12,] 0.00000000 0.00000000 0.000000000 0.00000000 0.19113142 0.52561140
#> [13,] 0.07466071 0.18582221 0.560785083 0.00000000 0.00000000 0.00000000
#> [14,] 0.00000000 0.00000000 0.355142838 0.00000000 0.00000000 0.00000000
#> [15,] 0.00000000 0.00000000 0.372597912 0.29807839 0.08279953 0.02815184
#> [16,] 0.26125456 0.11031956 0.036738914 0.15511986 0.07354637 0.03673891
#> [17,] 0.00000000 0.00000000 0.372597912 0.29807839 0.08279953 0.02815184
#> [18,] 0.00000000 0.00000000 0.000000000 0.00000000 0.00000000 0.00000000
#> [19,] 0.00000000 0.00000000 0.000000000 0.00000000 0.00000000 0.00000000
#> [20,] 0.00000000 0.00000000 0.000000000 0.00000000 0.00000000 0.00000000
#> [21,] 0.46657534 0.00000000 0.000000000 0.00000000 0.00000000 0.00000000
#> [22,] 0.00000000 0.00000000 0.000000000 0.00000000 0.00000000 0.00000000
#> [23,] 0.00000000 0.56884351 0.443697936 0.06826122 0.14789931 0.36405984
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